protein

Human Neuroserpin Protein (Recombinant) - LS-G27092

LS-G27092

LS-G27092

Human Neuroserpin Protein (Recombinant) - LS-G27092

Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. In the adult brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory, i.e. cerebral cortex, hippocampus, and amygdala. The neuroprotective role of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. The deficiency of neuroserpin in these mice was associated with motor neuron disease characterized by axonal degradation. In humans, defects in neuroserpin, caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy with neuroserpin inclusion bodies (FENIB).

Lyophilized from PBS

Recombinant

Human

Hamster-Chinese

Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.

Greater than 95% by SDS-PAGE and HPLC

40-45 kDa (SDS-PAGE)

Neuroserpin

SERPINI1

SERPINI1, Neuroserpin, Peptidase inhibitor 12, PI12, Serpin I1, PI-12, Protease inhibitor 12

Worldwide