protein

CXCL7 / PPBP Protein (Recombinant) (Ile46-Ile107) - LS-G27008

LS-G27008

LS-G27008

CXCL7 / PPBP Protein (Recombinant) (Ile46-Ile107) - LS-G27008

Rat NAP-2/CXCL7 is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP). Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR-2 and recruit and active ateneutrophils through chemotaxis. Although CTAP-III, Beta-TG and PBP represent amino-terminal extended variants of NAP-2 and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. NAP-2 stimulates various processes including mitogenesis, synthesis of the extracellular matrix, glucose metabolism and synthesis of plasminogen activator. Recently, it has been shown that the additional amino-terminal residues of CTAP-III mask the critical ELR receptor binding domain that is exposed on NAP-2 and may account for lack of NAP-2 activity.Recombinant Rat NAP-2 /CXCL7 produced in E.coli is a single non-glycosylated polypeptide chain containing 62 amino acids. A fully biologically active molecule, rrNAP-2/CXCL7 has a molecular mass of 6.9 kD analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.

Lyophilized from PBS

Recombinant

E. coli

Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 3 months.

Greater than 95% by SDS-PAGE

6.9 kDa (SDS-PAGE)

CXCL7 / PPBP

PPBP

Intercrine alpha

Intercrine

PPBP, Beta-thromboglobulin, B-TG1, Beta-TG, C-X-C motif chemokine 7, CTAP3, CXCL7, CTAP-III, CXC chemokine ligand 7, NAP-2, NAP-2-L1, PBP, LA-PF4, LDGF, SCYB7, Small-inducible cytokine B7, Small inducible cytokine B7, THBGB1, Thrombocidin 2, TC2, TGB, Thrombocidin 1, Thromboglobulin, beta-1, CTAPIII, MDGF, Platelet basic protein, SCAR10, TC1, THBGB

Worldwide