This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
SELE / CD62E / E-selectin Antibody (clone 4D10, FITC) LS-C96263
catalog :
LS-C96263
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
4D10

The same clone is also sold as:
reactivity :
human
product information
AntibodyID :
97750
AntibodyName :
LS-C96263
TargetSpecies :
Human
Host Species :
Rat
Product Name :
SELE / CD62E / E-selectin Antibody (clone 4D10, FITC) LS-C96263
Specificity :
The antigen is CD62E, the epitope has not been characterized. Antigen distribution: Isolated cells: Positive on LPS, TNFa, IL-1, or TPA stimulated endothelial cells (HUVECs) in tissue culture. No cross reactivity with other cell types known. Tissue sections: Strongly positive on human endothelial cells in acutely inflamed tissues such as atopic dermatitis or contact dermatitis 24h after sensitization; in the healthy spleen and lymph node. Few single cells express the 4D10 antigen. The antigen is generally absent in chronically inflamed tissues. Biochemistry: The antigen is a 589 amino acid transmembrane protein. It consists of a C-type lectin-like domain, an epidermal growth factor (EGF)-like domain, six short consensus repeat (SCR) domains, a transmembrane domain and a cytoplasmic tail. CD62E is a counter-receptor for sialyl Lewis X, sialyl Lewis a and CLA (cutaneous lymphocyte antigen). It is involved in adhesion between myeloid cells and activated endothelium, and supports leucocytes rolling. Some skin-associated memory T cells express CLA, and it may be that CD62E is also involved in their homing to cutaneous sites of chronic inflammation. In addition, CD62E may also be involved in tumour metastasis. A soluble form of CD62E has been reported to mediate angiogenesis in pathological disorders. Specificity: Human: CD62E. Other: Not tested.
ClonalityDesc :
Monoclonal
CloneName :
4D10
AntibodyModification :
FITC
PresentationDesc :
PBS pH 7.2, 10mg/ml BSA, 0.1% sodium azide
ImmunogenDesc :
LPS-stimulated human endothelial cells
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C.
Gene :
SELE / CD62E / E-selectin
StandardGeneSymbol :
SELE
Reactivity :
Human
ShortWebDescription :
E-selectin antibody LS-C96263 is an FITC-conjugated rat monoclonal antibody to human E-selectin (SELE / CD62E).
UsageText :
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Synonyms :
SELE, CD62E, ELAM, ESEL, E-selectin, LECAM2, CD62E antigen, ELAM-1, ELAM1, Selectin E
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.