product summary
request information :
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Anti-Melanoma
catalog :
LS-C95749
quantity :
price :
clonality :
monoclonal
host :
mouse
more info or order :
product information
?AntibodyID :
97126
AntibodyName :
LS-C95749
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
Anti-Melanoma
Specificity :
The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. has been shown to label the majority of melanomas. The MART-1/Melan A recognizes a protein of 18kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45 and the MART-1 (cocktail) and Tyrosinase make this quadruple antibody cocktail a first-order pan melanoma screener.
ClonalityDesc :
Monoclonal
CloneName :
HE12
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Pigmented melanoma metastases from lymph nodes (HMB45). Recombinant human MART-1 protein (MART1). Recombinant tyrosinase protein (Tyrosinase).
RecommendedStorageDesc :
Store at 2°C to 8°C degrees. Do not freeze.
Gene :
Melanoma
Reactivity :
Human
more info or order :
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
Seattle, WA 98121
antibodies@lsbio.com
www.lsbio.com1-206-464-1554
headquarters: usa
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.