product summary
Loading...
company name :
LifeSpan Biosciences
product type :
antibody
product name :
IL-10 Antibody (clone IL10/2651R) LS-C751212
catalog :
LS-C751212
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
IL10/2651R
reactivity :
human
application :
immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Reference
Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, et al. Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps. Allergol Int. 2016;65:96-102 pubmed publisher
product information
AntibodyID :
776848
AntibodyName :
LS-C751212
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
IL-10 Antibody (clone IL10/2651R) LS-C751212
Specificity :
Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
ClonalityDesc :
Recombinant Monoclonal
CloneName :
IL10/2651R
AntibodyModification :
Unconjugated
PresentationDesc :
1 mM PBS, 0.05% BSA, 0.05% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant full-length human Interleukin 10 (IL10) protein. Antigen Molecular Weight: 20 kDa (Monomer) - 37 kDa (Dimer)
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at 2°C to 8°C for up to 2 years.
IsotypeName :
IgG
Gene :
IL-10
StandardGeneSymbol :
IL10
gene family :
Hormone
Reactivity :
Human
Usage :
IHC-P (1 - 2 µg/ml)
ShortWebDescription :
IL-10 antibody LS-C751212 is an unconjugated rabbit recombinant monoclonal antibody to human IL-10. Validated for IHC. Cited in 1 publication.
UsageText :
Immunohistology (Formalin-fixed - 1-2 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Synonyms :
IL10, CSIF, GVHDS, IL-10, IL10A, Interleukin-10, Interleukin 10, TGIF
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.