This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
BACE1 / BACE Antibody LS-C74520
catalog :
LS-C74520
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, neutralization, immunoprecipitation
product information
AntibodyID :
75146
AntibodyName :
LS-C74520
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
BACE1 / BACE Antibody LS-C74520
Specificity :
Recognizes human BACE-1 ectodomain. Species cross-reactivity: Mouse.
ClonalityDesc :
Monoclonal
AntibodyModification :
Unconjugated
PresentationDesc :
Lyophilized PBS, pH 7.4, 5% Trehalose
ImmunogenType :
Recombinant protein
ImmunogenDesc :
NS0-derived rhBACE-1 ectodomain.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Lyophilized and resuspended forms: store at -20°C.
ResuspensionLiquidDesc :
Reconstitute in sterile PBS.
IsotypeName :
IgG1
Gene :
BACE1 / BACE
StandardGeneSymbol :
BACE1
gene family :
Protease
Subfamily :
Aspartic A1
Reactivity :
Mouse, Human
Usage :
ELISA, IP, Neut, WB
ShortWebDescription :
BACE antibody LS-C74520 is an unconjugated mouse monoclonal antibody to BACE (BACE1) from human. It is reactive with human and mouse. Validated for ELISA, IP, Neut and WB.
UsageText :
Suitable for use in ELISA, Immunoprecipitation/ Western Blot and Neutralization. The enzyme was then assayed with a peptide substrate. 50% of the proteolytic activity was inhibited by the antibody at 10 ug/ml (IC50) under conditions in which the enzyme was present at 10 ug/ml and the substrate concentration was 10uM. Considering the molecular masses of the enzyme (75kD) and the antibody (150kD), IC50 was achieved at ~0.5:1 molar ratio of the antibody to the enzyme. Did not inhibit rhCathepsin D activity under the same conditions.
Synonyms :
BACE1, APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, Aspartylprotease 2, Beta-secretase, Beta-site APP-cleaving enzyme, BACE, HSPC104, KIAA1149, B-Secretase, Beta-secretase 1, Memapsin-2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.