This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
MUC16 / CA125 Antibody (Extracellular Domain, clone X75) LS-C58422
catalog :
LS-C58422
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
X75

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
58892
AntibodyName :
LS-C58422
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
MUC16 / CA125 Antibody (Extracellular Domain, clone X75) LS-C58422
Specificity :
Recognizes the ovarian cancer mucin CA125 (also known as MUC16). CA125 consists of a short cytoplasmic tail, a transmembrane domain and an exceptionally large glycosylated extracellular domain. The extracellular domain is dominated by a large number of 156-amino acid repeat units, over 60 in all. These repeats are known to bind the antibodies OC125 and M11. CA125 is present within normal ovarian, endometrium, endocervix and fallopian tissue, but levels are elevated in over 90% of women with advanced ovarian cancer. CA125 levels may also be elevated in other cancers and non-cancerous conditions such as peritonitis, endometriosis and liver cirrhosis. Levels may also fluctuate during the menstrual cycle and occasionally increases in pregnancy, making CA125 an unreliable marker for ovarian cancer in premenopausal women. The function of CA125 in healthy tissue is unknown but it is thought to provide a protective lubricating barrier against particles and infectious agents at mucosal surfaces. CA125 was concluded by the International Society of Oncology and BioMarkers (ISOBM) to contain two major antigenic domains. Recognizes the epitope specificity group B, similar to the M-11 antibody. May be used as a capture antibody in ELISA assays.
ClonalityDesc :
Monoclonal
CloneName :
X75
AntibodyModification :
Unconjugated
AntigenModification :
Extracellular Domain
PresentationDesc :
TBS, 0.09% Sodium Azide
ImmunogenDesc :
CA125 antigen purified from human ovarian carcinoma
PurificationDesc :
Ion exchange chromatography
RecommendedStorageDesc :
Store at 4°C or at -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG1
Gene :
MUC16 / CA125
StandardGeneSymbol :
MUC16
Reactivity :
Human
Usage :
ELISA, WB
ShortWebDescription :
CA125 antibody LS-C58422 is an unconjugated mouse monoclonal antibody to human CA125 (MUC16) (Extracellular Domain). Validated for ELISA and WB.
UsageText :
ELISA: This product may be used in an indirect ELISA or as a detection antibody in a sandwich ELISA together with LS-B2829 as a capture reagent.
Synonyms :
MUC16, CA125 ovarian cancer antigen, CA125, CA-125, MUC-16, Mucin-16
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.