This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
LF / Lethal Factor Antibody (clone LFA58) LS-C58344
catalog :
LS-C58344
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
LFA58
reactivity :
anthrax bacterium
application :
western blot, ELISA
product information
AntibodyID :
58814
AntibodyName :
LS-C58344
TargetSpecies :
Bacteria
Host Species :
Mouse
Product Name :
LF / Lethal Factor Antibody (clone LFA58) LS-C58344
Specificity :
Recognizes the Lethal Factor of the anthrax toxin. Bacillus anthracis produces a toxin composed of three proteins, the Protective Antigen (PA), the Edema Factor (EF) and the Lethal Factor (LF). The three proteins depend on each other for their toxic effect. Both EF and LF functions intracellularly but are too large to enter the cell through existing channels. The PA is responsible for transporting the EF and LF into cells. The LF acts as an endoprotease, removing the N-terminus of mitogen-activated protein kinase kinases (MAPKK). The kinases are prevented from binding to their substrates, which leads to altered signalling pathways and ultimately to apoptosis. May be used as a capture antibody in ELISA assays for the Lethal Factor of Bacillus anthracis.
ClonalityDesc :
Monoclonal
CloneName :
LFA58
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenDesc :
Highly purified Bacillus anthracis lethal factor.
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
LF / Lethal Factor
StandardGeneSymbol :
lef
gene family :
Toxin
Reactivity :
Bacteria
Usage :
ELISA, WB
ShortWebDescription :
Lethal Factor antibody LS-C58344 is an unconjugated mouse monoclonal antibody to bacteria Lethal Factor (LF). Validated for ELISA and WB.
Synonyms :
lef, Lethal Factor, LF
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.