This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
PA / Protective Antigen Antibody (clone BAP0102) LS-C58343
catalog :
LS-C58343
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BAP0102
application :
western blot, ELISA
product information
AntibodyID :
58813
AntibodyName :
LS-C58343
TargetSpecies :
Bacteria
Host Species :
Mouse
Product Name :
PA / Protective Antigen Antibody (clone BAP0102) LS-C58343
Specificity :
Recognizes the Protective Antigen of the anthrax toxin. Bacillus anthracis produces a toxin composed of three proteins, the Protective Antigen (PA), the Edema Factor (EF) and the Lethal Factor (LF). The three proteins depend on each other for their toxic effect. Both EF and LF functions intracellularly but are too large to enter the cell through existing channels. The PA is responsible for transporting the EF and LF into cells. The 83kD PA (PA83) binds to the cell surface where a 20 kD N-terminal fragment (PA20) is cleaved off, exposing binding sites for LF and EF. The remaining 63 kD portion (PA63) oligomerizes to form a heptamer pre-pore, which then associates with up to three molecules of EF and/or LF. The receptor complex is internalized within endocytotic vessels that are subsequently acidified, transforming the PA heptamer into a pore that releases the active enzymes EF (an adenylate cyclase) and LF (a protease targeting MAPKKs) into the cytosol. Does not cross-react with the Lethal Factor of Bacillus anthracis, Yersinia pestis, Francisella tularensis or Toxoplasma gondii. Recognizes both the 83kD and 63kD truncated form of PA.
ClonalityDesc :
Monoclonal
CloneName :
BAP0102
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Purified protein
ImmunogenDesc :
Highly purified protective antigen of Bacillus anthracis.
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2b
Gene :
PA / Protective Antigen
StandardGeneSymbol :
pagA
gene family :
Virulence Factor
Reactivity :
Bacteria
Usage :
ELISA, WB
ShortWebDescription :
Protective Antigen antibody LS-C58343 is an unconjugated mouse monoclonal antibody to bacteria Protective Antigen (PA). Validated for ELISA and WB.
Synonyms :
pagA, PagA, pagA protective antigen, Protective antigen
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.