This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
TNFRSF1A / TNFR1 Antibody (clone H398, Azide-free) LS-C58333
catalog :
LS-C58333
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H398
reactivity :
human
application :
immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
product information
AntibodyID :
58803
AntibodyName :
LS-C58333
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
TNFRSF1A / TNFR1 Antibody (clone H398, Azide-free) LS-C58333
Specificity :
Recognizes both the 60kD cell surface and soluble fragment of human CD120a, otherwise known as TNF receptor type I (TNFR1/sTNFR1), a ubiquitously expressed transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily, which plays a key role in regulating the inflammatory response, acting as a receptor for tumor necrosis factor alpha (TNF-alpha) and lymphotoxin-alpha (TNF-beta). CD120a also plays a role in apoptosis, cytokine induction, cell differentiation, tumor necrosis and early stages of graft-versus-host disease, and its soluble form sTNFR1, acts as an inhibitor of TNF-alpha induced responses by acting as a decoy receptor. Clone H398 completely inhibits functional activity via CD120a by inhibiting receptor signalling, but does not always inhibit ligand binding of TNF. Clone H398 has been used successfully in functional studies on U937, K562, Colo 205, YT, MCF-7, HeLa and L929 cells.
ClonalityDesc :
Monoclonal
CloneName :
H398
AntibodyModification :
Azide-free Unconjugated
PresentationDesc :
PBS
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant CD120a (60kD).
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at 4°C or -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG2a
Gene :
TNFRSF1A / TNFR1
StandardGeneSymbol :
TNFRSF1A
gene family :
TNF Receptor
Reactivity :
Human
NonReactiveSpecies :
Mouse
Usage :
Flo, Func (10 µg/ml), IHC, IHC-Fr, IP
UsageNotRecommended :
IHC-P
ShortWebDescription :
TNFR1 antibody LS-C58333 is an unconjugated mouse monoclonal antibody to human TNFR1 (TNFRSF1A ). Validated for Flow, Func, IHC and IP.
UsageText :
Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Synonyms :
TNFRSF1A, CD120a, CD120a antigen, MS5, p60, TBP1, TNF-R55, TNFAR, TNFR1, p55-R, TNF-R, TNF-R-I, TNF-R1, TNF-RI, Tnfr, TNFR-I, TNFR1-d2, TNFR60, FPF, p55, Tbpi, TNFR55
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.