This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
TNNI3 / Cardiac Troponin I Antibody (aa20-24, clone 22B11) LS-C58316
catalog :
LS-C58316
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
22B11

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
58786
AntibodyName :
LS-C58316
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
TNNI3 / Cardiac Troponin I Antibody (aa20-24, clone 22B11) LS-C58316
Specificity :
Recognizes the dephosphorylated form of human cardiac Troponin I (cTnI). Troponin I is a 24kD subunit of Troponin, a protein found on muscle tissue responsible for muscle contraction. When calcium binds to Troponin C, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles. This allows cross-bridging to occur and the muscle to contract. Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death. Phosphorylation of cTnI results in changes in the activity and function of Troponin. One possible form of phosphorylation is by Protein kinase A. Protein kinase A phosphorylation of serine 22 and serine 23 reduces calcium sensitivity of Troponin and leads to an acceleration in relaxation. Changes in cTnI phosphorylation have been reported in failing hearts. Recognizes the dephosphorylated form of cTnI. Recognizes amino acid residues 20-24 on cTnI. The antibody will recognize free dephosphorylated cTnI or dephosphorylated cTnI in complex with other troponin components. Does not cross react with phosphorylated cTnI or with skeletal TnI.
ClonalityDesc :
Monoclonal
CloneName :
22B11
AntibodyModification :
Unconjugated
AntigenModification :
aa20-24
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenDesc :
Dephosphorylated form of human cardiac Troponin I.
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2b
Gene :
TNNI3 / Cardiac Troponin I
StandardGeneSymbol :
TNNI3
Reactivity :
Human
Usage :
ELISA, WB
ShortWebDescription :
Cardiac Troponin I antibody LS-C58316 is an unconjugated mouse monoclonal antibody to human Cardiac Troponin I (TNNI3) (aa20-24). Validated for ELISA and WB.
Synonyms :
TNNI3, CTnI, CMD1FF, CMD2A, RCM1, Troponin I, cardiac, Troponin I, cardiac muscle, Troponin I type 3 (cardiac), Cardiac troponin I, CMH7
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.