This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CYCS / Cytochrome c Antibody (clone 2G8) LS-C58283
catalog :
LS-C58283
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2G8

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
product information
AntibodyID :
58753
AntibodyName :
LS-C58283
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
CYCS / Cytochrome c Antibody (clone 2G8) LS-C58283
Specificity :
Recognizes cytochrome c, originally termed Apaf-2, an evolutionarily conserved protein which acts as an essential mitochondrial electron carrier between respirable substrates and oxygen, during aerobic energy production. A second major function for cytochrome c is its role as an intermediate in apoptosis, both through its association with inositol-3-phosphate receptor (IP3 receptor) which acts as an ER calcium release channel, and its association with apoptotic protease activating factor 1 (Apaf-1), resulting in the formation of the apoptosome protein complex which then recruits and activates pro-caspase 9 (Apaf-3). Clone 2G8 is reported to block the role of cytochrome c as a co-factor in the activation of caspase 9. Removal of sodium azide is recommended prior to use in functional assays.
ClonalityDesc :
Monoclonal
CloneName :
2G8
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Purified protein
ImmunogenDesc :
Human cytochrome C
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
CYCS / Cytochrome c
StandardGeneSymbol :
CYCS
Reactivity :
Human
Usage :
ELISA, Flo
ShortWebDescription :
Cytochrome c antibody LS-C58283 is an unconjugated mouse monoclonal antibody to human Cytochrome c (CYCS). Validated for ELISA and Flow.
UsageText :
Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request.
Synonyms :
CYCS, CYC, HCS, THC4, Cytochrome c, Cytochrome c, somatic
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.