This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
ABCB1 / MDR1 / P Glycoprotein Antibody (clone UIC2) LS-C58240
catalog :
LS-C58240
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
UIC2

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
58710
AntibodyName :
LS-C58240
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
ABCB1 / MDR1 / P Glycoprotein Antibody (clone UIC2) LS-C58240
Specificity :
Recognizes an extracellular conformational epitope of CD243, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein), a transmembrane protein and member of the ABC transporter (ATP-binding cassette) family, which acts as an active efflux pump for a diverse range of lipophillic compounds. CD243 is expressed at low levels in the cell membrane of peripheral blood leucocytes, and constitutively expressed on the apical plasma membrane of excretory epithelial cells of the kidney, liver, brain and small intestine. Strong inhibitor of CD243-mediated efflux and of the resistance of MDR cells to CD243 transported cytotoxic drugs. Can be used in a shift assay to selectively demonstrate the expression and functional activity of CD243 in a target cell. Does not cross-react with mitochondrial pyruvate carboxylase.
ClonalityDesc :
Monoclonal
CloneName :
UIC2
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Cells
ImmunogenDesc :
Mouse Balb/c 3T3 fibroblasts transfected with human CD243 cDNA.
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
ABCB1 / MDR1 / P Glycoprotein
StandardGeneSymbol :
ABCB1
gene family :
Transporter
Subfamily :
ATP-binding cassette - ABCB/MDR
Reactivity :
Human
NonReactiveSpecies :
Mouse, Rat
Usage :
Flo (1:50 - 1:200), IF, IHC, IHC-Fr, IHC-P, IP
ShortWebDescription :
P Glycoprotein antibody LS-C58240 is an unconjugated mouse monoclonal antibody to human P Glycoprotein (ABCB1 / MDR1). Validated for Flow, IF, IHC and IP.
UsageText :
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100ul. Immunohistochemistry: This product may benefit from antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose (3-4). Histology Positive Control Tissue: Human kidney.
Synonyms :
ABCB1, ABC20, Abcb1b, CLCS, Colchicin sensitivity, CD243, IBD13, gp170, MDR1, Multidrug resistance protein 1, P glycoprotein, P-glycoprotein 1, P-GP, CD243 antigen, PGY1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.