This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
PV1 / PLVAP Antibody (clone MECA-32) LS-C58134
catalog :
LS-C58134
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MECA-32

The same clone is also sold as:
reactivity :
human, mouse
application :
immunohistochemistry, immunohistochemistry - frozen section
product information
AntibodyID :
58604
AntibodyName :
LS-C58134
TargetSpecies :
Mouse
Host Species :
Rat
Product Name :
PV1 / PLVAP Antibody (clone MECA-32) LS-C58134
Specificity :
Recognizes murine plasmalemma vesicle-associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumor angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.
ClonalityDesc :
Monoclonal
CloneName :
MECA-32
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Recombinant protein
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
PV1 / PLVAP
StandardGeneSymbol :
PLVAP
Reactivity :
Mouse
Usage :
IHC, IHC-Fr (1:25 - 1:100)
ShortWebDescription :
PLVAP antibody LS-C58134 is an unconjugated rat monoclonal antibody to mouse PLVAP (PV1). Validated for IHC.
UsageText :
Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request.
Synonyms :
PLVAP, gp68, FELS, Plasmalemma vesicle protein 1, PV-1, PV1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.