This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CD275 / B7-H2 / ICOS Ligand Antibody (clone MIH11, FITC) LS-C58043
catalog :
LS-C58043
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
MIH11
reactivity :
human
application :
immunohistochemistry, flow cytometry, immunohistochemistry - frozen section
product information
AntibodyID :
58513
AntibodyName :
LS-C58043
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
CD275 / B7-H2 / ICOS Ligand Antibody (clone MIH11, FITC) LS-C58043
Specificity :
Detects CD275, also known as ICOS ligand (inducible T cell co-stimulator ligand). CD275 is a member of the B7 family, and interaction with its receptor CD278 (ICOS) plays an important role in T cell co-stimulation and inflammatory immune reactions. CD275 is expressed on activated B-cells, monocytes and dendritic cells and is also induced on non-lymphoid tissue cells such as endothelial cells, epithelial cells and muscle cells. CD275 has an important physiological role in the reactivation of effector/memory T cells on the endothelium, thus controlling entry of immune cells into inflamed tissue. The CD278-CD275 pathway is thought to be critical in the immune response to transplants, allergies and autoimmune diseases. Reported to partially block the interaction between CD275 and CD278.
ClonalityDesc :
Monoclonal
CloneName :
MIH11
AntibodyModification :
FITC
PresentationDesc :
PBS, 0.09% Sodium Azide, 1% BSA
ImmunogenType :
Cells
ImmunogenDesc :
CD275 - L cells.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Protect from light. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
CD275 / B7-H2 / ICOS Ligand
StandardGeneSymbol :
ICOSLG
Reactivity :
Human
Usage :
Flo (1:1 - 1:5), IHC, IHC-Fr
ShortWebDescription :
ICOS Ligand antibody LS-C58043 is an FITC-conjugated mouse monoclonal antibody to human ICOS Ligand (CD275 / B7-H2 ). Validated for Flow and IHC.
UsageText :
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request.
Synonyms :
ICOSLG, B7RP1, B7 homolog 2, B7 homologue 2, B7-H2, B7H2, B7RP-1, CD275 antigen, ICOS ligand, GL50, ICOS-L, ICOSL, KIAA0653, B7-like protein Gl50, B7-related protein 1, CD275, LICOS
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.