This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
BRCC3 / BRCC36 Antibody (N-Terminus) LS-C56931
catalog :
LS-C56931
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry - paraffin section
product information
AntibodyID :
57401
AntibodyName :
LS-C56931
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
BRCC3 / BRCC36 Antibody (N-Terminus) LS-C56931
Specificity :
AHP1465 recognizes human BRCA1/BRCA2 complex subunit 36 (BRCC36), a 36.7kD nuclear protein. BRCC36, together with BRCA1, BRCA2, Rad51 and BRCC45, forms a holoenzyme complex that possesses an ubiquitin E3 ligase activity. Studies have demonstrated that BRCC36 functions in enhancing cellular survival following DNA damage and that it is essential for ionizing radiation induced BRCA1 phosphorylation and nuclear foci formation. Research has shown that BRCC36 is aberrantly expressed in the majority of breast tumors indicating a potential role in the pathogenesis of the disease. It has been hypothesized that BRCC36 could be a potentially important target in the treatment of radiation-resistant breast tumors.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
N-Terminus
PresentationDesc :
PBS, 0.02% Sodium Azide
ImmunogenDesc :
An 18 amino acid peptide near the N-Terminus of human BRCC36.
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
BRCC3 / BRCC36
StandardGeneSymbol :
BRCC3
Reactivity :
Human
Usage :
IHC-P, WB (0.5 - 1 µg/ml)
ShortWebDescription :
BRCC36 antibody LS-C56931 is an unconjugated rabbit polyclonal antibody to human BRCC36 (BRCC3) (N-Terminus). Validated for IHC and WB.
UsageText :
Western Blot: LS-C56931 detects a band of approximately 36kD in MCF7 cell lysates.
Synonyms :
BRCC3, C6.1A, BRCC36, BRISC complex subunit BRCC36, BRCA1-A complex subunit BRCC36, CXorf53, RP11-143H17.2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.