This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
4-Hydroxynonenal Antibody (Serum) LS-C56815
catalog :
LS-C56815
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
application :
western blot, ELISA
product information
AntibodyID :
57285
AntibodyName :
LS-C56815
TargetSpecies :
Broad
Host Species :
Goat
Product Name :
4-Hydroxynonenal Antibody (Serum) LS-C56815
Specificity :
Recognizes 4-hydroxynonenal (HNE). A 65 kD, highly reactive aldehyde released upon oxidation of omega-6-insaturated fatty acids, often by free radicals. HNE acts to spread and increase the initial effects of free radical events. It binds nucleic acids, phospholipids and sulfhydryl, histidine and lysine groups. These conjugates cause the cytotoxic effects (including cell death) that occur during oxidative stress due to hydrogen peroxide, superoxide, UV, heat and oxidant chemicals. HNE plays a role in the pathogenesis of diseases, stimulating fibrogenesis and inflammation. It is thought to act as a sensor of external stimuli, inducing the stress response by modulating membrane receptors such as Epidermal growth factor receptor or Fas. It is thought that constitutive levels of HNE may be needed for normal cell functions as decreased HNE levels are associated with cell proliferation and increased HNE levels with elevated apoptosis.
ClonalityDesc :
Polyclonal
AntibodyModification :
Serum Unconjugated
PresentationDesc :
0.09% Sodium Azide
ImmunogenDesc :
4-hydroxynonenal conjugate.
PurificationDesc :
Antiserum
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
4-Hydroxynonenal
Reactivity :
Broad
Usage :
ELISA (1:10000), WB (1:3000)
ShortWebDescription :
4-Hydroxynonenal antibody LS-C56815 is an unconjugated goat polyclonal antibody to broad 4-Hydroxynonenal. Validated for ELISA and WB.
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.