This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
WNT5A Antibody (aa 62-380) LS-C500023
catalog :
LS-C500023
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
product information
AntibodyID :
513537
AntibodyName :
LS-C500023
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
WNT5A Antibody (aa 62-380) LS-C500023
Specificity :
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa 62-380
PresentationDesc :
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant Human Protein Wnt-5a protein (62-380AA)
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
IsotypeName :
IgG
Gene :
WNT5A
StandardGeneSymbol :
WNT5A
gene family :
WNT
Reactivity :
Mouse, Human
Usage :
ELISA, IF, IHC, WB
ShortWebDescription :
WNT5A antibody LS-C500023 is an unconjugated rabbit polyclonal antibody to WNT5A (aa 62-380) from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
Synonyms :
WNT5A, HWNT5A, Protein Wnt-5a, WNT-5A protein
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.