This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
KLRK1 / CD314 / NKG2D Antibody LS-C499208
catalog :
LS-C499208
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
immunohistochemistry, immunocytochemistry
product information
AntibodyID :
512722
AntibodyName :
LS-C499208
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
KLRK1 / CD314 / NKG2D Antibody LS-C499208
Specificity :
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant Human NKG2-D type II integral membrane protein (73-216AA)
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Short term: store at -20°C. Long term: store at -80°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG
Gene :
KLRK1 / CD314 / NKG2D
StandardGeneSymbol :
KLRK1
Reactivity :
Human
Usage :
ELISA, IF, IHC
ShortWebDescription :
NKG2D antibody LS-C499208 is an unconjugated rabbit polyclonal antibody to human NKG2D (KLRK1 / CD314). Validated for ELISA, IF and IHC.
Synonyms :
KLRK1, D12S2489E, CD314 antigen, KLR, NK cell receptor D, NKG2D, NKG2-D, NKG2-D-activating NK receptor, CD314
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.