This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
GAPDH Antibody (Biotin) LS-C498273
catalog :
LS-C498273
clonality :
polyclonal
host :
domestic rabbit
conjugate :
biotin
reactivity :
human
product information
AntibodyID :
511787
AntibodyName :
LS-C498273
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
GAPDH Antibody (Biotin) LS-C498273
Specificity :
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
ClonalityDesc :
Polyclonal
AntibodyModification :
Biotin
PresentationDesc :
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant Human Glyceraldehyde-3-phosphate dehydrogenase protein (2-335AA)
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
IsotypeName :
IgG
Gene :
GAPDH
StandardGeneSymbol :
GAPDH
Reactivity :
Human
Usage :
ELISA
ShortWebDescription :
GAPDH antibody LS-C498273 is a biotin-conjugated rabbit polyclonal antibody to human GAPDH. Validated for ELISA.
Synonyms :
GAPDH, A1 40 kd subunit, Activator 1 40 kd subunit, G3PD, GAPD, G3pdh, Rfc40, Rf-c 40 kd subunit
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.