product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
PLAP / Alkaline Phosphatase Antibody (clone 8B6) LS-C49111
catalog :
LS-C49111
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8B6
reactivity :
human, mouse, rat, chicken
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000
Lee Kubli C, Ingves M, Henry K, Shiao R, Collyer E, Tuszynski M, et al. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016;278:91-104 pubmed publisher
  • immunocytochemistry; mouse; 1:1000
Wang Y, Wu Q, Yang P, Wang C, Liu J, Ding W, et al. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun. 2016;7:10481 pubmed publisher
  • immunocytochemistry; mouse
Kizuka Y, Nakano M, Kitazume S, Saito T, Saido T, Taniguchi N. Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem J. 2016;473:21-30 pubmed publisher
  • immunocytochemistry; human
Ahn S, Kim T, Kim K, Chung S. Differentiation of human pluripotent stem cells into Medial Ganglionic Eminence vs. Caudal Ganglionic Eminence cells. Methods. 2016;101:103-12 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Shimada M, Dumitrache L, Russell H, McKinnon P. Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015;34:2465-80 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Kuo B, Baldwin E, Layman W, Taketo M, Zuo J. In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of β-Catenin and Atoh1. J Neurosci. 2015;35:10786-98 pubmed publisher
  • immunocytochemistry; human; 1:1000
Fimiani C, Goina E, Mallamaci A. Upregulating endogenous genes by an RNA-programmable artificial transactivator. Nucleic Acids Res. 2015;43:7850-64 pubmed publisher
  • immunocytochemistry; mouse; 1:500
Liu Y, Miao Q, Yuan J, Han S, Zhang P, Li S, et al. Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo. J Neurosci. 2015;35:9336-55 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Maza I, Caspi I, Zviran A, Chomsky E, Rais Y, Viukov S, et al. Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nat Biotechnol. 2015;33:769-74 pubmed publisher
  • immunocytochemistry; mouse
Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, De Strooper B, et al. Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. Cell Rep. 2015;11:1176-83 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Luna Sánchez M, Díaz Casado E, Barca E, Tejada M, Montilla García Ã, Cobos E, et al. The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene. EMBO Mol Med. 2015;7:670-87 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Liu Z, Brunskill E, Boyle S, Chen S, Turkoz M, Guo Y, et al. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development. 2015;142:1193-202 pubmed publisher
  • immunocytochemistry; human; 1:100
Maury Y, Côme J, Piskorowski R, Salah Mohellibi N, Chevaleyre V, Peschanski M, et al. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes. Nat Biotechnol. 2015;33:89-96 pubmed publisher
  • immunocytochemistry; rat; 1:200
Chau M, Deveau T, Song M, Gu X, Chen D, Wei L. iPSC Transplantation increases regeneration and functional recovery after ischemic stroke in neonatal rats. Stem Cells. 2014;32:3075-87 pubmed publisher
  • western blot; mouse
Herrera F, Yamaguchi T, Roelink H, Tjian R. Core promoter factor TAF9B regulates neuronal gene expression. elife. 2014;3:e02559 pubmed publisher
  • immunohistochemistry; chicken; 1:500
Herrera A, Saade M, Menendez A, Marti E, Pons S. Sustained Wnt/?-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole. Nat Commun. 2014;5:4168 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Ngo L, Haas M, Qu Z, Li S, Zenker J, Teng K, et al. TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons. Hum Mol Genet. 2014;23:5147-58 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Katyal S, Lee Y, Nitiss K, Downing S, Li Y, Shimada M, et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014;17:813-21 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
Hatakeyama J, Wakamatsu Y, Nagafuchi A, Kageyama R, Shigemoto R, Shimamura K. Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development. 2014;141:1671-82 pubmed publisher
  • immunohistochemistry - frozen section; chicken; 1:400
Lee K, Seo J, Shin J, Ji E, Roh J, Kim J, et al. Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system. Proc Natl Acad Sci U S A. 2014;111:2794-9 pubmed publisher
product information
AntibodyID :
49348
AntibodyName :
LS-C49111
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
PLAP / Alkaline Phosphatase Antibody (clone 8B6) LS-C49111
Specificity :
Alkaline Phosphatase, Placental - both Regan and Nagao isoenzymes. No cross reactivity with other isoenzymes of Alkaline Phosphatase.
ClonalityDesc :
Monoclonal
CloneName :
8B6
AntibodyModification :
Unconjugated
PresentationDesc :
Tris-glycine, 0.15M NaCl, 0.05% sodium azide
ImmunogenType :
Cells
ImmunogenDesc :
HEp-2 cells with boosted surface expression of PLAP.
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.
Gene :
PLAP / Alkaline Phosphatase
StandardGeneSymbol :
ALPP
Reactivity :
Human
Usage :
ELISA, IF, IHC, IHC-Fr, IHC-P
ShortWebDescription :
Alkaline Phosphatase antibody LS-C49111 is an unconjugated mouse monoclonal antibody to human Alkaline Phosphatase (PLAP). Validated for ELISA, IF and IHC.
Synonyms :
ALPP, ALP, Alkaline phosphomonoesterase, Glycerophosphatase, PALP, PLAP, PLAP-1, Alp1, Germ-cell alkaline phosphatase, Nagao isozyme, Regan isozyme
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.