This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CRYAB / Alpha B Crystallin Antibody (aa1-175, clone 2E8) LS-C45027
catalog :
LS-C45027
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2E8

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
44765
AntibodyName :
LS-C45027
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
CRYAB / Alpha B Crystallin Antibody (aa1-175, clone 2E8) LS-C45027
Specificity :
Recognizes alpha B crystallin, a 20kD water-soluble major structural protein and member of the heat shock protein family, designated HSPB5, which acts as a molecular chaperone and is believed to play a role in the maintenance of ocular lens transparency/refractive index. Besides the involvement of both alpha A and alpha B crystallin in the prevention of protein precipitation and cataract formation in the eye, alpha crystallins have also been demonstrated in other tissues including the heart, brain, kidney, spleen and thymus. Studies have shown that a mutation in alpha B crystallin is responsible for desmin-related myopathy (DRM) and cataract(1), and that alpha B crystallin is a major component of the astrocytic inclusions known as Rosenthal fibers (RFs), found in Alexander's disease.
ClonalityDesc :
Monoclonal
CloneName :
2E8
AntibodyModification :
Unconjugated
AntigenModification :
aa1-175
PresentationDesc :
PBS, 0.02% Sodium Azide, 10% Glycerol
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant human alpha B crystallin (1-175aa) purified from E. coli.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2b
Gene :
CRYAB / Alpha B Crystallin
StandardGeneSymbol :
CRYAB
Reactivity :
Human
Usage :
ELISA, WB (1:1000 - 1:2000)
ShortWebDescription :
Alpha B Crystallin antibody LS-C45027 is an unconjugated mouse monoclonal antibody to human Alpha B Crystallin (CRYAB) (aa1-175). Validated for ELISA and WB.
UsageText :
Western Blot: LS-C45027 detects a band of approximately 20kD in mouse eye cell lysates.
Synonyms :
CRYAB, Alpha-crystallin B chain, CRYA2, Crystallin, alpha B, CTPP2, Heat shock protein beta-5, HSPB5, Alpha B Crystallin, Alpha(B)-crystallin, Rosenthal fiber component, Heat-shock 20 kD like-protein
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.