This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CFH / Complement Factor H Antibody (clone 10-10) LS-C44982
catalog :
LS-C44982
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
10-10

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, flow cytometry, immunohistochemistry - frozen section
product information
AntibodyID :
44720
AntibodyName :
LS-C44982
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
CFH / Complement Factor H Antibody (clone 10-10) LS-C44982
Specificity :
Recognizes human complement factor H which exists in 2 forms. The most common form, of 150 kD, and the less common form of 43 kD. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.
ClonalityDesc :
Monoclonal
CloneName :
10-10
AntibodyModification :
Unconjugated
PresentationDesc :
BBS, 0.1% Sodium Azide
ImmunogenDesc :
Purified human factor H from serum.
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
CFH / Complement Factor H
StandardGeneSymbol :
CFH
Reactivity :
Human
Usage :
ELISA, Flo, IHC-Fr, WB
ShortWebDescription :
Complement Factor H antibody LS-C44982 is an unconjugated mouse monoclonal antibody to human Complement Factor H (CFH). Validated for ELISA, Flow, IHC and WB.
Synonyms :
CFH, Adrenomedullin binding protein, AHUS1, AMBP1, ARMS1, ARMD4, Beta-1-H-globulin, Factor H, Factor H-like 1, HF, HF2, H factor 1, H factor 2 (complement), HUS, HF1, Beta-1H, CFHL3, Complement factor H, H factor 1 (complement)
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.