CLU / Clusterin Antibody (clone 3R3/2) LS-C44980 | LifeSpan Biosciences LS-C44980 product information

product summary

company name :

LifeSpan Biosciences

product type :

antibody

product name :

CLU / Clusterin Antibody (clone 3R3/2) LS-C44980

catalog :

LS-C44980

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3R3/2

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

LifeSpan Biosciences product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human	Yang Y, Keene C, Peskind E, Galasko D, Hu S, Cudaback E, et al. Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. J Neuropathol Exp Neurol. 2015;74:672-87 pubmed publisher

product information

AntibodyID :

44718

AntibodyName :

LS-C44980

TargetSpecies :

Human

Host Species :

Mouse

Product Name :

CLU / Clusterin Antibody (clone 3R3/2) LS-C44980

Specificity :

Recognizes clusterin, an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localized to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitize cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.

ClonalityDesc :

Monoclonal

CloneName :

3R3/2

AntibodyModification :

Unconjugated

PresentationDesc :

BBS, 0.1% Sodium Azide

ImmunogenDesc :

Glomerular basement membrane from a post-mortem kidney.

PurificationDesc :

Protein A purified

RecommendedStorageDesc :

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

IsotypeName :

IgG1

Gene :

CLU / Clusterin

StandardGeneSymbol :

CLU

Reactivity :

Human

Usage :

ELISA, Flo, IHC, IHC-Fr, WB

ShortWebDescription :

Clusterin antibody LS-C44980 is an unconjugated mouse monoclonal antibody to human Clusterin (CLU). Validated for ELISA, Flow, IHC and WB. Cited in 1 publication.

Synonyms :

CLU, APO-J, Apolipoprotein J, CLU1, Clusterin, Complement lysis inhibitor, CLI, AAG4, Aging-associated protein 4, Ku70-binding protein 1, KUB1, SGP2, APOJ, SGP-2, Sulfated glycoprotein 2, CLU2, Complement cytolysis inhibitor, NA1/NA2, SP-40

SalesRegion :

Worldwide

more info or order :

LifeSpan Biosciences product webpage

company information

LifeSpan Biosciences

2401 Fourth Avenue, Suite 900
Seattle, WA 98121

CustomerSupport@lsbio.com

https://www.lsbio.com

1-206-464-1554

headquarters: USA

Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.