This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Complement C5 Antibody (N-Terminus, clone 046-10.2.2 (10-04)) LS-C44979
catalog :
LS-C44979
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
046-10.2.2 (10-04)

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
44717
AntibodyName :
LS-C44979
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
Complement C5 Antibody (N-Terminus, clone 046-10.2.2 (10-04)) LS-C44979
Specificity :
Recognizes secreted complement component 5 (C5), a 190kD serine protease present in blood serum. It is composed of an 115kD disulphide linked alpha-chain and a 75 kD beta-chain. In addition to its role in complement, C5 is thought to be associated with inflammation, stimulating tumor necrosis factor alpha, interferon gamma mediated suppression of IL10 and IL12 production. C5 is activated via either the classical or the alternative complement pathway, by proteolytic cleavage of C5a from the N-terminal of the alpha-chain, by C5 convertase. C5a is an anaphylatoxin which mediates local inflammation. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. It also stimulates chemotaxis of neutrophils, eosinophils, basophils and monocytes towards the site of inflammation. The remaining fragment, C5b, initiates the assembly of the membrane attack complex. In hemolysis inhibition studies it was found that Will block C5 hemolytic activity. Removal of sodium azide is recommended prior to use in functional assays. XXX XXX recommend the use of EUQOO3 for this purpose.
ClonalityDesc :
Monoclonal
CloneName :
046-10.2.2 (10-04)
AntibodyModification :
Unconjugated
AntigenModification :
N-Terminus
PresentationDesc :
BBS, 0.1% Sodium Azide
ImmunogenDesc :
Purified human C5.
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
Complement C5
StandardGeneSymbol :
C5
Reactivity :
Human
Usage :
ELISA, WB
ShortWebDescription :
Complement C5 antibody LS-C44979 is an unconjugated mouse monoclonal antibody to human Complement C5 (N-Terminus). Validated for ELISA and WB.
Synonyms :
C5, Anaphylatoxin C5a analog, CPAMD4, Complement C5, Complement component 5
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.