This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Complement C3 Antibody (clone 10-21) LS-C44973
catalog :
LS-C44973
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
10-21

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
44711
AntibodyName :
LS-C44973
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
Complement C3 Antibody (clone 10-21) LS-C44973
Specificity :
Recognizes 9 kD complement component 3a (C3a) which is present in the blood serum. C3a is generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3a and C3b, which is further degraded into iC3b and C3dg/C3d. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. C3a mediates local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3a is expressed at significantly higher levels in colorectal cancer. Shows minimal reactivity with other complement proteins in radioimmunoassays and hemagglutination. Clone 10-21 has been reported to work in western blotting applications.
ClonalityDesc :
Monoclonal
CloneName :
10-21
AntibodyModification :
Unconjugated
PresentationDesc :
BBS, 0.1% Sodium Azide
ImmunogenDesc :
Native purified human C3a.
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
Complement C3
StandardGeneSymbol :
C3
Reactivity :
Human
Usage :
ELISA (1:1500 - 1:6000), WB
ShortWebDescription :
Complement C3 antibody LS-C44973 is an unconjugated mouse monoclonal antibody to human Complement C3. Validated for ELISA and WB.
Synonyms :
C3, AHUS5, ARMD9, Complement component C3, CPAMD1, Complement C3, ASP, Complement component 3
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.