This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
TRAIL-R3 / DCR1 Antibody (clone 2B8, FITC) LS-C44963
catalog :
LS-C44963
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
2B8

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
product information
AntibodyID :
44701
AntibodyName :
LS-C44963
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
TRAIL-R3 / DCR1 Antibody (clone 2B8, FITC) LS-C44963
Specificity :
Recognizes human CD263, a 60 Kd cell surface protein, which is otherwise known as decoy receptor 1 (DcR1). CD263 is a member of the tumor necrosis factor (TNF) receptor superfamily that binds to TNF-related apoptosis inducing ligand (TRAIL). As the receptor does not possess cytoplasmic death domains it cannot induce apoptosis, but instead plays an important role in inhibiting TRAIL-induced apoptosis. CD263 is expressed in normal tissues including heart, skeletal tissues and peripheral blood neutrophils, but weakly expressed in tumor cells. The 2B8 antibody does not inhibit DcR1 (CD263) inhibitory function in TRAIL-induced apoptosis.
ClonalityDesc :
Monoclonal
CloneName :
2B8
AntibodyModification :
FITC
PresentationDesc :
PBS, 0.09% Sodium Azide, 1% BSA
ImmunogenType :
Purified protein
ImmunogenDesc :
DcR1-Fc chimeric protein
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Protect from light. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
TRAIL-R3 / DCR1
StandardGeneSymbol :
TNFRSF10C
gene family :
TNF Receptor
Reactivity :
Human
Usage :
Flo (1:1 - 1:10)
ShortWebDescription :
DCR1 antibody LS-C44963 is an FITC-conjugated mouse monoclonal antibody to human DCR1 (TRAIL-R3). Validated for Flow.
UsageText :
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request.
Synonyms :
TNFRSF10C, CD263 antigen, CD263, Cytotoxic TRAIL receptor-3, Decoy receptor 1, DCR1, DCR1-TNFR, LIT, Lymphocyte inhibitor of TRAIL, TRAIL-R3, TRAILR3, TRAIL receptor 3, TRID
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.