This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
LYN Antibody (aa8-238, clone LYN01) LS-C44852
catalog :
LS-C44852
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
LYN01

The same clone is also sold as:
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation
product information
AntibodyID :
44590
AntibodyName :
LS-C44852
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
LYN Antibody (aa8-238, clone LYN01) LS-C44852
Specificity :
Recognizes p56/p53lyn (lyn), a 56kD member of the src family of non-receptor protein tyrosine kinases (PTKs), predominantly expressed in tissues of hematopoietic origin. The interaction between lyn and syk, is crucial for regulating the response of both mast cells and basophils, following Fc epsilon R1 receptor aggregation and activation. Once activated, the rapid tyrosine phosphorylation of ITAMs by lyn, serves as a binding site for the recruitment and activation of syk, triggering the phosphorylation of further adaptor and signaling molecules further down a complex signaling cascade. This chain of events involving receptor aggregation, activation and tyrosine phosphorylation of ITAMs, is also vital for the survival and differentiation of B cells through the interaction of lyn and syk with the B cell receptor (BCR).
ClonalityDesc :
Monoclonal
CloneName :
LYN01
AntibodyModification :
Unconjugated
AntigenModification :
aa8-238
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant fragment of human Lyn (aa8-238).
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG1
Gene :
LYN
StandardGeneSymbol :
LYN
gene family :
Protein Kinase
Subfamily :
Src
Reactivity :
Human
Usage :
IF, IP, WB (1:100 - 1:1000)
ShortWebDescription :
LYN antibody LS-C44852 is an unconjugated mouse monoclonal antibody to human LYN (aa8-238). Validated for IF, IP and WB.
UsageText :
Western Blot: LS-C44852 detects a band of approximately 53-56kD in human peripheral blood monocytes.
Synonyms :
LYN, Lyn protein tyrosine kinase, Lyn ptk, Lyn tyrosine kinase, p56Lyn, p53Lyn, Tyrosine-protein kinase Lyn, JTK8, Lyn kinase
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.