product summary
request information :
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Anti-KLRK1 / CD314 / NKG2D
catalog :
LS-C44802
quantity :
price :
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
immunoprecipitation, flow cytometry
more info or order :
LifeSpan Biosciences product webpage
product information
?AntibodyID :
44540
AntibodyName :
LS-C44802
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
Anti-KLRK1 / CD314 / NKG2D
Specificity :
Specific for CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to CD314 results in NK cell activation and potent costimulation of effector T cells. Clone 5C6 is reported to inhibit T cell recognition of MICA (1, 3)
ClonalityDesc :
Monoclonal
AntibodyModification :
Low Endotoxin
PresentationDesc :
PBS, pH 7.4.
ImmunogenDesc :
NKL cells.
PurificationDesc :
Protein G purified
IsotypeName :
IgG2a
Gene :
KLRK1 / CD314 / NKG2D
StandardGeneSymbol :
KLRK1
Reactivity :
Human
Usage :
Flo (1:100 - 1:200), Func, IP
UsageText :
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.
Synonyms :
KLRK1, D12S2489E, CD314 antigen, KLR, NK cell receptor D, NKG2D, NKG2-D, NKG2-D-activating NK receptor, CD314
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.