product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
TLR4 Antibody (clone HTA125, Low Endotoxin) LS-C44224
catalog :
LS-C44224
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HTA125
reactivity :
human
application :
western blot, immunoprecipitation, flow cytometry
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Reference
Huang W, Liu Y, Li L, Zhang R, Liu W, Wu J, et al. HMGB1 increases permeability of the endothelial cell monolayer via RAGE and Src family tyrosine kinase pathways. Inflammation. 2012;35:350-62 pubmed publisher
product information
AntibodyID :
43962
AntibodyName :
LS-C44224
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
TLR4 Antibody (clone HTA125, Low Endotoxin) LS-C44224
Specificity :
Recognizes the human Toll like receptor 4 (TLR4) cell surface antigen. TLR4, also known as CD284, has been demonstrated to act as a receptor for LPS on human monocytes and macrophages. TLR4 signalling of LPS stimulation requires the presence of the MD-2 molecule. TLR4 is weakly expressed by resting cells, but is upregulated following stimulation with LPS. Has been demonstrated to block activation of monocytes with LPS.
ClonalityDesc :
Monoclonal
CloneName :
HTA125
AntibodyModification :
Low Endotoxin Unconjugated
PresentationDesc :
PBS
ImmunogenType :
Cells
ImmunogenDesc :
Ba/F3 cell line expressing TLR4 (CD284)
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
TLR4
StandardGeneSymbol :
TLR4
gene family :
Toll-like Receptor
Reactivity :
Human
Usage :
Flo (1:10 - 1:50), IP, WB
UsageNotRecommended :
IHC-P
ShortWebDescription :
TLR4 antibody LS-C44224 is an unconjugated mouse monoclonal antibody to human TLR4. Validated for Flow, IP and WB.
UsageText :
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells or 100 ul whole blood. Method sheets are available on request.
Synonyms :
TLR4, CD284, CD284 antigen, Homolog of Drosophila toll, TLR-4, TOLL, ARMD10, Toll-like receptor 4, HToll
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.