This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Anti-CD71 / Transferrin Receptor Antibody (clone OX-26) LS-C43743
catalog :
LS-C43743
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OX-26
reactivity :
human, rat
application :
flow cytometry, immunohistochemistry - frozen section
product information
AntibodyID :
43481
AntibodyName :
LS-C43743
TargetSpecies :
Rat
Host Species :
Mouse
Product Name :
Anti-CD71 / Transferrin Receptor Antibody (clone OX-26) LS-C43743
Specificity :
Recognizes rat CD71, also known as transferrin receptor, a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Clone 0X-26 also binds to a number of non-dividing normal tissues. The balance between a sufficient amount of iron uptake and prevention of accumulation of excess iron within a cell, is vitally important to maintain cellular functions such as oxygen and electron transport and mitochondrial energy metabolism, whilst preventing permanent cell and tissue damage. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialized proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis. An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimer's, Parkinson's, Huntington's and Multiple Sclerosis. Is reported as suitable for use in immunoelectron microscopy. OX-26 detects a band of ~95kD in Western blotting under reducing conditions and ~195kD under non-reducing conditions reflecting it's homodimeric structure.
ClonalityDesc :
Monoclonal
CloneName :
OX-26
AntibodyModification :
Unconjugated
PresentationDesc :
PBS, 0.09% sodium azide.
ImmunogenType :
Cells
ImmunogenDesc :
PHA activated rat lymphocytes.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
+4°C or -20°C, Avoid repeated freezing and thawing.
IsotypeName :
IgG2a
Gene :
CD71 / Transferrin Receptor
StandardGeneSymbol :
TFRC
gene family :
Protease
Subfamily :
Metallopeptidase M28B
Reactivity :
Rat
Usage :
Flo (1:50 - 1:200), IHC-Fr
UsageText :
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul.
Synonyms :
TFRC, CD71, TFR1, TRFR, TFR, TR, CD71 antigen, p90, T9, Transferrin receptor, Transferrin receptor protein 1
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.