This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
NK1.1 / NK Cells Antibody (clone PK136, Preservative Free) LS-C43395
catalog :
LS-C43395
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
PK136
reactivity :
mouse
application :
immunoprecipitation, flow cytometry
product information
AntibodyID :
43133
AntibodyName :
LS-C43395
TargetSpecies :
Mouse
Host Species :
Mouse
Product Name :
NK1.1 / NK Cells Antibody (clone PK136, Preservative Free) LS-C43395
Specificity :
Recognizes the mouse NK1.1 cell surface antigen, a cell surface glycoprotein encoded by members of the NKR-P1 gene family. The NK1.1 surface antigen is also known as CD161b/CD161c and Ly-55. In the mouse the NKR-P1 family has three members, NKR-P1A, -B and -C, whilst in the human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, -b, -c etc. Although previously thought to recognize only CD161c, recent data has shown that the PK136 antibody may also react with CD161b. CD161c expression itself is strain specific in mice, but recognition of CD161b by PK136 appears to be even more complex, as only some CD161b positive strains are labeled by the antibody. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. Is useful for the identification of NK cells in selected strains of mice (positive on C57BL, FVB/N and NZB, but negative on AKR and BALB/c) and is also expressed by rare subsets of T cells and monocytes. Has also been used for in vivo depletion of NK cells and in vitro activation of NK cells.
ClonalityDesc :
Monoclonal
CloneName :
PK136
AntibodyModification :
Preservative Free Unconjugated
PresentationDesc :
PBS
ImmunogenType :
Cells
ImmunogenDesc :
Spleen and bone marrow cells from CE mice.
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG2a
Gene :
NK1.1 / NK Cells
StandardGeneSymbol :
NK1.1
Reactivity :
Mouse
NonReactiveSpecies :
Rat, Human
Usage :
Flo (5 - 10 µg/ml), IP
ShortWebDescription :
NK Cells antibody LS-C43395 is an unconjugated mouse monoclonal antibody to mouse NK Cells (NK1.1). Validated for Flow and IP.
UsageText :
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 1 x 10^6 cells in 100 ul. Method sheets are available on request.
Synonyms :
, NK1.1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.