This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
EIF4EBP1 / 4EBP1 Antibody (C-Terminus) LS-C43158
catalog :
LS-C43158
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
product information
AntibodyID :
42896
AntibodyName :
LS-C43158
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
EIF4EBP1 / 4EBP1 Antibody (C-Terminus) LS-C43158
Specificity :
Recognizes an epitope within the C-terminal region (CT) of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1), a rapamycin-sensitive downstream target of TOR (Target of rapamycin), and regulatory factor of eukaryotic mRNA translation. The association between 4EPB1 and eukaryotic translation initiation factor 4E (eIF-4E) inhibits the binding of eIF-4E with p220, thereby preventing the formation of a functional eIF-4E complex, essential for mRNA translation. Phosphorylation of 4EBP1 following stimulation by mitogens such as insulin, results in the release of eIF-4E from 4EBP1, thereby enabling the translation complex to assemble.(AHP993) has been reported as suitable for use in IHC on mouse 3T3 cell cytospins.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
C-Terminus
PresentationDesc :
PBS, 0.02% Sodium Azide
ImmunogenDesc :
A 14 AA peptide located near human 4EBP1 C-Terminus.
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
EIF4EBP1 / 4EBP1
StandardGeneSymbol :
EIF4EBP1
Reactivity :
Human
Usage :
WB (2.5 - 5 µg/ml)
ShortWebDescription :
4EBP1 antibody LS-C43158 is an unconjugated rabbit polyclonal antibody to human 4EBP1 (EIF4EBP1) (C-Terminus). Validated for WB.
UsageText :
Western Blot: LS-C43158 detects a band of approximately 20kD in mouse 3T3 cell lysates. (predicted MW 13kD).
Synonyms :
EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, EIF4E-binding protein 1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.