This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
FEN1 Antibody (N-Terminus) LS-C43020
catalog :
LS-C43020
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunoprecipitation
product information
AntibodyID :
42758
AntibodyName :
LS-C43020
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
FEN1 Antibody (N-Terminus) LS-C43020
Specificity :
Recognizes human Flap endonuclease 1 also known as Flap structure-specific endonuclease, FEN1, Maturation factor 1 or DNase IV. FEN1 is a 380 amino acid ~45kD member of the FEN1 sub family of XPG/RAD2 endonucleases which has an important role in lagging strand DNA synthesis and base excision repair. It is hypothesised that FEN1 may play a role in the inhibition of triplet repeat expansion. Two isoforms of FEN1 are generated by alternative initiation, isoform 1 against whichis generated and a truncated isoform FENMIT, lacking the N-terminal region and having a mitochondrial distribution, FENMIT also lacks DNAse activity. Initial results suggest thatdoes not recognize the truncated form of human FEN1. Fen1 is expressed in the nucleus of a wide variety of organ structures notably in those of the hematopoietic system including spleen, lymph nodes and spleen. Recognizes a band of ~45kD in whole cell lysates of HeLa and 293T by western blotting and has successfully been used for immunoprecipitation of FEN1 from HeLa cell lysates.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
N-Terminus
PresentationDesc :
Tris-Citrate/PBS, 0.09% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to a region within the N-Terminus domain of human FEN1 (locus link ID 2237).
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at 4°C. Do not freeze. Store undiluted. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
FEN1
StandardGeneSymbol :
FEN1
Reactivity :
Human
Usage :
IP, WB (1:5000 - 1:30000)
ShortWebDescription :
FEN1 antibody LS-C43020 is an unconjugated rabbit polyclonal antibody to human FEN1 (N-Terminus). Validated for IP and WB.
UsageText :
Western Blot: LS-C43020 detects a band of approximately 42kD in Hela cell lysates.
Synonyms :
FEN1, DNase IV, FEN-1, HFEN-1, Flap endonuclease 1, MF1, RAD2, Maturation factor 1, Maturation factor-1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.