product summary
request information :
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Anti-CCL3 / MIP-1-Alpha
catalog :
LS-C42987
quantity :
price :
clonality :
polyclonal
host :
goat
reactivity :
human
application :
western blot, ELISA
more info or order :
LifeSpan Biosciences product webpage
product information
?AntibodyID :
42725
AntibodyName :
LS-C42987
TargetSpecies :
Human
Host Species :
Goat
Product Name :
Anti-CCL3 / MIP-1-Alpha
Specificity :
Specific for human MIP-1 alpha, otherwise known as CCL3, a 69 amino acid member of the CC chemokine family which plays a critical role in hematopoiesis and is shown to signal through the chemokine receptors CCR1, CCR4 and CCR5. MIP-1 alpha is also involved in host defense against invading pathogens, acting as a regulator of activation and trafficking of inflammatory cells, such as macrophages, NK cells, granulocytes, dendritic cells and CD8+ lymphocytes. The recruitment of inflammatory cells by MIP-1 alpha, has been linked with the pathogenesis of several diseases, including rheumatoid arthritis, H. pylori associated gastritis and bacterial meningitis. The secretion of MIP-1 alpha by CD8+ lymphocytes has been shown to act as a major HIV-suppressive factor (HIV-SF) through binding to CCR5, identified as a coreceptor for HIV-1 target cell entry
ClonalityDesc :
Polyclonal
PresentationDesc :
Lyophilized, PBS, pH 7.4.
ImmunogenDesc :
Recombinant human MIP-1 alpha.
PurificationDesc :
Purified
ResuspensionLiquidDesc :
Distilled Water. For long term storage the addition of 0.09% sodium azide is recommended. For functional studies do not add azide.
IsotypeName :
IgG
Gene :
CCL3 / MIP-1-Alpha
StandardGeneSymbol :
CCL3
gene family :
Intercrine
Subfamily :
Intercrine beta
Reactivity :
Human
Usage :
ELISA (0.5 µg/ml), WB (0.1 - 0.2 µg/ml)
Synonyms :
CCL3, C-C motif chemokine 3, G0S19-1, Mip1alpha, SCYA3, SIS-beta, Chemokine (C-C motif) ligand 3, LD78ALPHA, MIP-1-alpha, MIP1A, PAT 464.1, Small-inducible cytokine A3
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.