This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
PSEN1 / Presenilin 1 Antibody (N-Terminus) LS-C42920
catalog :
LS-C42920
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - frozen section
product information
AntibodyID :
42658
AntibodyName :
LS-C42920
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
PSEN1 / Presenilin 1 Antibody (N-Terminus) LS-C42920
Specificity :
Recognizes presenilin-1 (PSEN1), an integral membrane protein that is widely expressed, especially in brain tissue. PSEN1 is an essential component of the gamma-secretase complex, along with APH-1 (APH-1A or APH-1B), PSEN2, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes. Mutations of presenilin-1 are associated with early onset Alzheimer's disease.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
N-Terminus
PresentationDesc :
Serum, 0.02% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide derived from N-terminus of human presenilin-1. (N-TERMINAL).
IsotypeName :
IgG
Gene :
PSEN1 / Presenilin 1
StandardGeneSymbol :
PSEN1
gene family :
protease
Subfamily :
Aspartic A22A
Reactivity :
Hamster, Human, Monkey
Usage :
IHC, IHC-Fr
ShortWebDescription :
Presenilin 1 antibody LS-C42920 is an unconjugated rabbit polyclonal antibody to Presenilin 1 (PSEN1 ) from human, hamster and monkey. Validated for IHC.
Synonyms :
PSEN1, AD3, Alzheimer disease 3, FAD, Protein S182, PS1, S182, PS-1, PSNL1, Presenilin 1, Presenilin-1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.