This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
APP / Beta Amyloid Precursor Antibody (aa292-312, Serum) LS-C42917
catalog :
LS-C42917
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunoprecipitation, immunohistochemistry - paraffin section
product information
AntibodyID :
42655
AntibodyName :
LS-C42917
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
APP / Beta Amyloid Precursor Antibody (aa292-312, Serum) LS-C42917
Specificity :
Recognizes an epitope in the Kunitz protease inhibitor (KPI) domain of human amyloid precursor protein (APP). Only the APP-751 and APP-770 isoforms contain a KPI domain, it being absent from the APP-695 isoform that is most abundant in neuronal tissue. However, there is evidence that suggests KPI containing isoforms may be important in the pathogenesis of Alzheimer disease. Recognizes a band of ~115kD in NTera2/DI cell lysates using western blotting under reducing conditions.
ClonalityDesc :
Polyclonal
AntibodyModification :
Serum Unconjugated
AntigenModification :
aa292-312
PresentationDesc :
0.02% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP.
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
APP / Beta Amyloid Precursor
StandardGeneSymbol :
APP
gene family :
Amyloid precursor protein
Reactivity :
Human
Usage :
IHC-P (1:400), IP (1:1), WB (1:500 - 1:1000)
ShortWebDescription :
Beta Amyloid Precursor antibody LS-C42917 is an unconjugated rabbit polyclonal antibody to human Beta Amyloid Precursor (APP) (aa292-312). Validated for IHC, IP and WB.
UsageText :
Immunohistochemistry: This product requires antigen retrieval using heat treatment prior to staining of paraffin embedded sections. 0.05 M Tris pH7.0, followed by reduction and alkylation is recommended. Histology Positive Control Tissue: Alzheimer's disease brain Western Blot: LS-C42917 detects a band of approximately 115kD in NTera2/DI cell lysates.
Synonyms :
APP, ABPP, A4, ABETA, AD1, Alzheimer disease, Amyloid beta, Beta-amyloid peptide, APPI, Beta amyloid, CVAP, AAA, PN2, PreA4, Amyloid beta A4 protein, Peptidase nexin-II, CTFgamma, PN-II, Protease nexin-II
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.