This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
APP / Beta Amyloid Precursor Antibody (C-Terminus) LS-C42820
catalog :
LS-C42820
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry - paraffin section
product information
AntibodyID :
42558
AntibodyName :
LS-C42820
Host Species :
Rabbit
Product Name :
APP / Beta Amyloid Precursor Antibody (C-Terminus) LS-C42820
Specificity :
Recognizes both intact Amyloid Precursor Protein (APP), and also the C99 fragment generated by Beta-secretase. The sequence recognized by this corresponds to amino acids 85-99 of the C99 fragment. The C99 fragment itself is a substrate for gamma-secretase to generate the 4 kD beta amyloid peptide, found in the brains of Alzheimer's disease patients. APP also inhibits Notch signaling through it's interaction with NUMB. Has been used successfully for the detection of the ~14 kD beta C-terminal fragment of APP, produced as a result of cleavage by BACE1 using western blotting -in rat retinal lysates.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
C-Terminus
PresentationDesc :
PBS, 0.02% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to amino acids 737-751 of human APP (C-TERMINAL).
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
APP / Beta Amyloid Precursor
StandardGeneSymbol :
APP
gene family :
Amyloid precursor protein
Reactivity :
Mouse, Rat, Human
Usage :
IHC-P, WB (1:500 - 1:1000)
ShortWebDescription :
Beta Amyloid Precursor antibody LS-C42820 is an unconjugated rabbit polyclonal antibody to Beta Amyloid Precursor (APP) (C-Terminus) from human, mouse and rat. Validated for IHC and WB.
UsageText :
Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Synonyms :
APP, ABPP, A4, ABETA, AD1, Alzheimer disease, Amyloid beta, Beta-amyloid peptide, APPI, Beta amyloid, CVAP, AAA, PN2, PreA4, Amyloid beta A4 protein, Peptidase nexin-II, CTFgamma, PN-II, Protease nexin-II
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.