This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Anti-ERBB2 / HER2 Antibody (phospho-Thr686) LS-C42794
catalog :
LS-C42794
price :
385 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry - frozen section
product information
AntibodyID :
42532
AntibodyName :
LS-C42794
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
Anti-ERBB2 / HER2 Antibody (phospho-Thr686) LS-C42794
Specificity :
Recognizes human HER2/neu, otherwise known as CD340 and c-ErbB-2, phosphorylated at threonine residue (amino acid 686). Some binding to unphosphorylated HER2/neu may be seen at higher concentrations, but this may be overcome by appropriate titration. HER2/neu is a proto-oncogene expressed at the cell surface of a range of tumor cells, which is often associated with poor prognosis, and an increased risk of metastasis, and is used in conjunction with antibodies recognizing both Estrogen and Progesterone receptors, for the classification of breast cancer tumors, and to determine patient prognosis and course of treatment. Excessive HER2/neu is present in around 20% to 25% of invasive breast cancers, referred to as HER2-positive cancer, and can help determine whether drugs such as trastuzumab (Herceptin) or lapatinib (Tykerb), might be beneficial.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
pThr686
PresentationDesc :
Serum, 0.09% sodium azide.
ImmunogenDesc :
Threonine phosphorylated peptide KIRKYTMRRLL from CD340 sequence. ( pThr686 ). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Sheep, Hamster, Elephant, Panda, Cat, Bovine, Bat, Dog, Horse, Pig (100%); Opossum, Trichoplax (82%).
RecommendedStorageDesc :
+4°C or -20°C, Avoid repeated freezing and thawing. Store undiluted.
IsotypeName :
IgG
Gene :
ERBB2 / HER2
StandardGeneSymbol :
ERBB2
gene family :
Protein Kinase
Subfamily :
EGF Receptor
Reactivity :
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
Usage :
ELISA, IHC-Fr (1:500), WB (1:1000 - 1:5000)
UsageText :
Western Blot: For the detection of phosphoproteins, threonine phosphatase inhibitors such as 10 mM Sodium Fluoride should be added to the sample buffer. Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background.
Synonyms :
ERBB2, C-erb B2/neu protein, CD340, HER2, Herstatin, MLN 19, HER-2, Neu, NGL, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, CD340 antigen, MLN19, p185erbB2, TKR1
ProductID :
51890
ProductNumber :
LS-C42794-100
Volume :
100 µl
LSListPrice :
385 USD
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.