This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CCL5 / RANTES Antibody LS-C42727
catalog :
LS-C42727
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry - paraffin section
product information
AntibodyID :
42465
AntibodyName :
LS-C42727
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
CCL5 / RANTES Antibody LS-C42727
Specificity :
Recognizes human RANTES (regulated upon activation, normal T cell expressed and secreted), otherwise known as CCL5, a 68 amino acid CC- chemokine involved in T cell activation and cell recruitment, expressed by cytotoxic (CD8+) T cells (CTLs), macrophages, keratinocytes and endothelial cells. RANTES acts as a chemoattractant for monocytes, CD4+/CD45RO+ memory T cells, basophils and eosinophils, thorough binding to chemokine (C-C motif) receptor 1 (CCR1), CCR3 and CCR5. Both CCR3 and CCR5 are known co-receptors for the entry of HIV viruses into target cells and the binding of RANTES to CCR3 on CTLs has been shown to enhance HIV-1-specific cytotoxicity, whilst binding to CCR5 inhibits membrane fusion and hence HIV entry.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
PresentationDesc :
PBS
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant human RANTES.
PurificationDesc :
Purified
RecommendedStorageDesc :
Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
ResuspensionLiquidDesc :
Distilled Water. For long term storage the addition of 0.09% sodium azide is recommended. For functional studies do not add azide.
IsotypeName :
IgG
Gene :
CCL5 / RANTES
StandardGeneSymbol :
CCL5
gene family :
Intercrine
Reactivity :
Human
Usage :
ELISA (0.5 - 2 µg/ml), IHC-P, WB (0.1 - 0.2 µg/ml)
ShortWebDescription :
RANTES antibody LS-C42727 is an unconjugated rabbit polyclonal antibody to human RANTES (CCL5). Validated for ELISA, IHC and WB.
UsageText :
ELISA: May be used in an indirect ELISA or as a capture reagent in a sandwich ELISA. Western Blot: May be used in either reducing or non-reducing conditions.
Synonyms :
CCL5, Chemokine (C-C motif) ligand 5, D17S136E, EoCP, T-cell specific protein p288, SCYA5, SISd, T cell-specific protein P228, Beta-chemokine RANTES, C-C motif chemokine 5, RANTES, SIS-delta, Small-inducible cytokine A5, T-cell-specific protein RANTES, TCP228
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.