This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
MDM2 Antibody (aa177-195) LS-C42649
catalog :
LS-C42649
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA
product information
AntibodyID :
42387
AntibodyName :
LS-C42649
TargetSpecies :
Mouse
Host Species :
Rabbit
Product Name :
MDM2 Antibody (aa177-195) LS-C42649
Specificity :
Detects murine Mdm2, a nuclear phosphoprotein that controls intracellular levels of the tumor suppressor protein p53 by ubiquitination and subsequent proteasomal degradation. Mdm2 also interacts with the retinoblastoma (RB) protein and E2F-1, to promote G1-S phase transition in the cell cycle. Mdm2 activity is controlled by self-ubiquitination; however activation of the PI3K/PKB pathway leads to phosphorylation of Mdm2 at Ser185, which stabilizes the protein.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa177-195
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to aa 177-195 of mouse Mdm2.
PurificationDesc :
Purified IgG
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
MDM2
StandardGeneSymbol :
MDM2
Reactivity :
Mouse
Usage :
ELISA (1:3000 - 1:12000), WB (1:500 - 1:2000)
ShortWebDescription :
MDM2 antibody LS-C42649 is an unconjugated rabbit polyclonal antibody to mouse MDM2 (aa177-195). Validated for ELISA and WB.
UsageText :
Western Blot: LS-C42649 detects a band of approximately 90kD in mouse MEF cell lysates.
Synonyms :
MDM2, ACTFS, Double minute 2 protein, Hdm2, MDM2 variant FB30, HDMX, Oncoprotein Mdm2, p53-binding protein Mdm2, MDM2 variant FB28
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.