This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CHEK2 / CHK2 Antibody (phospho-Thr68) LS-C42576
catalog :
LS-C42576
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
42314
AntibodyName :
LS-C42576
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
CHEK2 / CHK2 Antibody (phospho-Thr68) LS-C42576
Specificity :
Detects human Checkpoint kinase 2 (Chk2), phosphorylated at threonine 68 (Thr68). Chk2 is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radiation, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2, leading to Chk2 dimerization and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphatase, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familial cancer usually associated with inherited mutations in TP53.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
pThr68
PresentationDesc :
PBS, pH 7.2, 0.01% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to amino acids 64-73 of human Chk2. (pThr68).
PurificationDesc :
Purified
IsotypeName :
IgG
Gene :
CHEK2 / CHK2
StandardGeneSymbol :
CHEK2
gene family :
Protein Kinase
Subfamily :
CDS1
Reactivity :
Human
Usage :
ELISA (1:10000 - 1:50000), WB (1:200 - 1:2000)
ShortWebDescription :
CHK2 antibody LS-C42576 is an unconjugated rabbit polyclonal antibody to human CHK2 (CHEK2 ). Validated for ELISA and WB.
UsageText :
Western Blot: LS-C42576 detects a band of approximately 61kD.
Synonyms :
CHEK2, BA444G7, Cds1 homolog, Checkpoint kinase 2, Checkpoint-like protein CHK2, CHK2 checkpoint homolog, CHK2, HCds1, LFS2, RAD53, Rad53 homolog, HCHK2, HuCds1, PP1425
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.