This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
ANK1 / Ankyrin Antibody (N-Terminus) LS-C41714
catalog :
LS-C41714
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
41452
AntibodyName :
LS-C41714
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
ANK1 / Ankyrin Antibody (N-Terminus) LS-C41714
Specificity :
Recognizes erythroid ankyrin (ankyrin-1), also known as ankyrin R or erythrocyte ankyrin. Ankyrin 1 is a 1881 amino acid ~220kD cytoplasmic protein forming an attachment for a number of integral membrane proteins and cytoskeletal elements. Ankyrin-1 contains a large number of repeats, a domain and two domains. Multiple isoforms of ankyrin-1 are generated by alternative splicing and promoter usage,is expected to recognize all erythrocyte isoforms of ankyrin-1 but is not expected to recognize the N-terminally truncated muscle isoforms of ankyrin-1. Additionallyis likely to cross react with ankyrin-1 from chimpanzee (Pan troglodytes) and lowland gorilla (Gorilla gorilla gorilla). Most ankyrins are composed of 3 structural domains; a N-terminal regulatory domain containing multiple ankyrin repeats, a central spectrin binding domain and a C-terminal regulatory domain. Ankyrin-1 is present in erythrocytes and has also been found in brain and muscle. Mutations in erythrocytic ankyrin-1 are associated with hereditary spherocytosis.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
N-Terminus
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to the amino acids 1 - 11 of the native protein conjugated to Keyhole Limpet Hemocyanin.
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 4°C or -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG
Gene :
ANK1 / Ankyrin
StandardGeneSymbol :
ANK1
Reactivity :
Human
Usage :
ELISA (1:10000 - 1:100000), WB
ShortWebDescription :
Ankyrin antibody LS-C41714 is an unconjugated rabbit polyclonal antibody to human Ankyrin (ANK1 ). Validated for ELISA and WB.
UsageText :
Western Blot: In blots of human erythrocytes bands of 220 kD were observed.
Synonyms :
ANK1, ANK-1, Ankyrin-1, Ankyrin-R, Erythrocyte ankyrin, ANK, Ankyrin, Ankyrin 1, erythrocytic, SPH2, SPH1
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.