product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
MAGEA1 / MAGE 1 Antibody (clone MA454, Azide-free, BSA-free) LS-C391567
catalog :
LS-C391567
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MA454
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Reference
Murata K, Nakatsugawa M, Rahman M, Nguyen L, Millar D, Mulder D, et al. Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma. elife. 2020;9: pubmed publisher
product information
AntibodyID :
403760
AntibodyName :
LS-C391567
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
MAGEA1 / MAGE 1 Antibody (clone MA454, Azide-free, BSA-free) LS-C391567
Specificity :
Human MAGEA1 / MAGE 1
ClonalityDesc :
Monoclonal
CloneName :
MA454
AntibodyModification :
Azide-free, BSA-free Unconjugated
PresentationDesc :
1X PBS
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Full length human protein.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at -20°C.
IsotypeName :
IgG1,k
Gene :
MAGEA1 / MAGE 1
StandardGeneSymbol :
MAGEA1
Reactivity :
Dog, Rat, Human
Usage :
Flo (0.5 - 1 µg/10E6 cells), IF (1 - 2 µg/ml), IHC, IHC-P (0.5 - 1 µg/ml), WB
ShortWebDescription :
MAGE 1 antibody LS-C391567 is an unconjugated mouse monoclonal antibody to MAGE 1 (MAGEA1) from human. It is reactive with human, rat and dog. Validated for Flow, IF, IHC and WB. Cited in 1 publication.
UsageText :
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Recognizes a protein of 42-46kDa, identified as MAGE-1. This mAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
Synonyms :
MAGEA1, Antigen MZ2-E, Cancer/testis antigen 1.1, CT1.1, MAGE-1 antigen, MAGE1A, Melanoma antigen family A 1, Melanoma antigen MAGE-1, MAGE 1, MAGE1, Melanoma-associated antigen 1
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.