product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
HSPG2 / Perlecan Antibody (clone A7L6) LS-C390348
catalog :
LS-C390348
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
A7L6
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Reference
Rios Navarro C, Ortega M, Marcos Garcés V, Gavara J, de Dios E, Perez Sole N, et al. Interstitial changes after reperfused myocardial infarction in swine: morphometric and genetic analysis. BMC Vet Res. 2020;16:262 pubmed publisher
product information
AntibodyID :
402541
AntibodyName :
LS-C390348
TargetSpecies :
Mouse
Host Species :
Rat
Product Name :
HSPG2 / Perlecan Antibody (clone A7L6) LS-C390348
Specificity :
Mouse HSPG2 / Perlecan
ClonalityDesc :
Monoclonal
CloneName :
A7L6
AntibodyModification :
Unconjugated
PresentationDesc :
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
ImmunogenDesc :
Murine EHS laminin preparation.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 2°C to 8°C.
IsotypeName :
IgG2a,k
Gene :
HSPG2 / Perlecan
StandardGeneSymbol :
HSPG2
Reactivity :
Mouse, Bovine, Pig, Human, Monkey
Usage :
Flo (0.5 - 1 µg/10E6 cells), IF (0.5 - 1 µg/ml), IHC, IHC-P (1 - 2 µg/ml)
ShortWebDescription :
Perlecan antibody LS-C390348 is an unconjugated rat monoclonal antibody to Perlecan (HSPG2) from mouse. It is reactive with human, mouse, bovine and other species. Validated for Flow, IF and IHC. Cited in 1 publication.
UsageText :
This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. Optimal dilution of the Perlecan antibody should be determined by the researcher. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Synonyms :
HSPG2, Endorepellin (domain V region), HSPG, Heparan sulfate proteoglycan 2, Perlecan, Perlecan proteoglycan, SJA, SJS1, PRCAN, SJS
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.