product summary
Loading...
company name :
LifeSpan Biosciences
product type :
antibody
product name :
STK11 / LKB1 Antibody (aa421-433) LS-C388827
catalog :
LS-C388827
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Reference
Wang L, Zhang S, Zhang W, Cheng G, Khan R, Junjvlieke Z, et al. miR-424 Promotes Bovine Adipogenesis Through an Unconventional Post-Transcriptional Regulation of STK11. Front Genet. 2020;11:145 pubmed publisher
product information
AntibodyID :
401020
AntibodyName :
LS-C388827
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
STK11 / LKB1 Antibody (aa421-433) LS-C388827
Specificity :
Human STK11 / LKB1
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa421-433
PresentationDesc :
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide from the C-Terminus of human STK11/LKB1 (SSKIRRLSACKQQ, aa421-433 of UniProt Q15831). Percent identity by BLAST analysis: Human, Ferret, Sheep, Cat, Bovine, Elephant, Horse, Pig, Guinea pig, Platypus, Dog (100%); Rat, Bat, Hamster (92%); Mouse, Turkey, Chicken, Medaka (85%).
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
ResuspensionLiquidDesc :
Reconstitute in sterile distilled water.
IsotypeName :
IgG
Gene :
STK11 / LKB1
StandardGeneSymbol :
STK11
gene family :
Protein Kinase
Subfamily :
CAMKL
Reactivity :
Mouse, Dog, Guinea pig, Sheep, Bovine, Pig, Horse, Human
Usage :
IHC, IHC-P (0.5 - 1 µg/ml), WB (0.5 - 1 µg/ml)
ShortWebDescription :
LKB1 antibody LS-C388827 is an unconjugated rabbit polyclonal antibody to LKB1 (STK11) (aa421-433) from human. It is reactive with human, mouse, bovine and other species. Validated for IHC and WB. Cited in 1 publication.
UsageText :
Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor Smith et al. (1999) found that the mouse Lkb1 gene encodes a protein showing strong sequence similarity to human protein. Karuman et al. (2001) demonstrated that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. Jenne et al. (1998) determined that the gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction. Smith et al. (1999) found that the mouse Lkb1 gene consists of 10 exons covering approximately 15 kb.
Synonyms :
STK11, HLKB1, Peutz-Jeghers syndrome, PJS, Serine/threonine kinase 11, Liver kinase B1, LKB1
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.