product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
PTPN6 / SHP1 Antibody (C-Terminus) LS-C358839
catalog :
LS-C358839
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2b
Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed publisher
Okubo K, Brenner M, Cullere X, Saggu G, Patchen M, Bose N, et al. Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling. Cell Rep. 2021;35:109142 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-C358839 image 1
Western blot analysis of SHPTP1 expression in HEK239A (A); NIH3T3 (B) whole cell lysates.
image 2 :
LifeSpan Biosciences LS-C358839 image 2
Immunohistochemical analysis of SHPTP1 staining in human lymph node formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
product information
AntibodyID :
370608
AntibodyName :
LS-C358839
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
PTPN6 / SHP1 Antibody (C-Terminus) LS-C358839
Specificity :
Recognizes endogenous levels of SHPTP1 protein.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
C-Terminus
PresentationDesc :
PBS, pH 7.3, 0.01% Sodium Azide, 30% Glycerol
ImmunogenType :
Synthetic peptide - KLH conjugated
ImmunogenDesc :
KLH-conjugated synthetic peptide encompassing a sequence within the C-Terminus of human SHPTP1.
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Aliquot and store at -20°C for 1 year. Avoid freeze/thaw cycles.
Gene :
PTPN6 / SHP1
BlockingPeptide :
LS-E42149
StandardGeneSymbol :
PTPN6
gene family :
Protein Phosphatase
Subfamily :
NT2
Reactivity :
Mouse, Human
Usage :
IHC, IHC-P (1:100 - 1:200), WB (1:500 - 1:1000)
ShortWebDescription :
SHP1 antibody LS-C358839 is an unconjugated rabbit polyclonal antibody to SHP1 (PTPN6) (C-Terminus) from human. It is reactive with human and mouse. Validated for IHC and WB. Cited in 1 publication.
Synonyms :
PTPN6, HCP, HPTP1C, Hematopoietic cell phosphatase, PTP-1C, SH-PTP1, SHP-1L, SHP-1, Shptp1, HCPH, PTP1C, SHP1
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.