This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
PGF / PLGF Antibody (aa206-221) LS-C358023
catalog :
LS-C358023
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
product information
AntibodyID :
369568
AntibodyName :
LS-C358023
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
PGF / PLGF Antibody (aa206-221) LS-C358023
Specificity :
Human PGF / PLGF
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa206-221
PresentationDesc :
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
A synthetic peptide corresponding to a sequence at the C-Terminus of human PLGF(206-221 aa REKMKPERCGDAVPRR). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey (100%); Cat (88%).
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.
ResuspensionLiquidDesc :
Reconstitute in sterile distilled water.
IsotypeName :
IgG
Gene :
PGF / PLGF
StandardGeneSymbol :
PGF
gene family :
PDGF
Reactivity :
Human, Monkey, Chimpanzee
Usage :
WB (0.5 - 1 µg/ml)
ShortWebDescription :
PLGF antibody LS-C358023 is an unconjugated rabbit polyclonal antibody to PLGF (PGF) (aa206-221) from human. It is reactive with human, chimpanzee and monkey. Validated for WB.
UsageText :
Placental growth factor(PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor(VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors(VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter- and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.
Synonyms :
PGF, D12S1900, PGFL, PlGF-2, Placental growth factor, Placental growth factor-like, PLGF, Placenta growth factor, SHGC-10760
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.