This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
IVL / Involucrin Antibody (clone SY5) LS-C357940
catalog :
LS-C357940
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SY5

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
product information
AntibodyID :
369485
AntibodyName :
LS-C357940
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
IVL / Involucrin Antibody (clone SY5) LS-C357940
Specificity :
Human IVL / Involucrin
ClonalityDesc :
Monoclonal
CloneName :
SY5
AntibodyModification :
Unconjugated
PresentationDesc :
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
ImmunogenType :
Cells
ImmunogenDesc :
Purified Involucrin from human keratinocytes.
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Store at 2°C to 8°C.
IsotypeName :
IgG1,k
Gene :
IVL / Involucrin
StandardGeneSymbol :
IVL
Reactivity :
Dog, Pig, Gorilla, Owl monkey, Human
NonReactiveSpecies :
Mouse
Usage :
Flo (0.5 - 1 µg/10E6 cells), IF (1 - 2 µg/ml), IHC, IHC-P (1 - 2 µg/ml)
ShortWebDescription :
Involucrin antibody LS-C357940 is an unconjugated mouse monoclonal antibody to Involucrin (IVL) from human. It is reactive with human, dog, gorilla and other species. Validated for Flow, IF and IHC.
UsageText :
This antibody recognizes a protein of 66-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this antibody reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, a doublet of ~115 and 150kDa in gorilla and owl monkey, 66kDa in dog, and a doublet of 105kDa in pig. Its epitope maps between amino acids 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal. expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
Synonyms :
IVL, Involucrin
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.