This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
DFFA / ICAD / DFF45 Antibody LS-C357931
catalog :
LS-C357931
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
product information
AntibodyID :
369476
AntibodyName :
LS-C357931
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
DFFA / ICAD / DFF45 Antibody LS-C357931
Specificity :
Human DFFA / ICAD / DFF45.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
PresentationDesc :
1X PBS, pH 7.4, 0.1 mg/ml BSA, 0.05% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
A recombinant protein fragment from human ICAD.
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG
Gene :
DFFA / ICAD / DFF45
StandardGeneSymbol :
DFFA
gene family :
DNase
Reactivity :
Mouse
Usage :
WB (4 - 8 µg/ml)
ShortWebDescription :
DFF45 antibody LS-C357931 is an unconjugated rabbit polyclonal antibody to mouse DFF45 (DFFA / ICAD). Validated for WB.
UsageText :
During apoptosis, toxic or useless cells are broken down for removal. DFF, or DNA fragmentation factor, is a heterodimeric protein which mediates DNA fragmentation and chromatin condensation during apoptosis. DFFB is the active DFF subunit but remains inactive while bound to DFFA, also call ICAD (Inhibitor of caspase-activated DNase). Caspase-3 cleaves ICAD, which then disassociates from DFFB. The disassociation removes the inhibitory effects of ICAD, activating DFFB and beginning the DNA fragmentation process.
Synonyms :
DFFA, DFF-45, DFF1, Dna fragmentation factor-45, ICAD, Inhibitor of CAD, DFF45
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.